This database was created through the pharmacological intervention of the SMOKEFREEBRAIN project (http://smokefreebrain.eu/). The scope of this intervention was to assess the possible effects of varenicline during the sleep of smokers. The intervention, namely the administration of varenicline was distinguished into two treatment periods. The first treatment period lasted for a maximum of 18 days. Prior and right after the first treatment period, the pre- and post- polysomnographic (PSG), behavioral, and clinical measurements were taken. The second treatment period initiated right after the second (post) PSG session and lasted for a maximum of 71 days. After the second treatment period, the follow-up behavioral, and clinical measurements were taken. Therefore, clinical, and behavioral data correspond to the pre and follow up stages of the intervention, while the PSG data correspond to the pre and post stages. There fewer subjects that reached the followup in comparison to the subjects that completed the post-stage (2nd PSG session). The success in smoking cessation was assessed through measurement of the cotinine levels after 12 weeks of varenicline treatment (pre-follow up).